Burden of UC

Time to ease the burden of living with ulcerative colitis

People living with inflammatory bowel disease (IBD) have significantly reduced health-related quality of life (QoL) compared with the general population.1

The impact of ulcerative colitis (UC) on QoL is multifaceted. It often affects individuals at a time in life when they are pursuing employment, building families, and reaching key milestones.2

The burden of UC can be physical, financial, and psychological.2

There is a high psychosocial burden on UC patients during the course of their disease.3

Photo of a man

“It’s a beautiful day at a park, but here I am, with my wife and my sons, desperately wishing I stayed at home…”

Photo of a woman

“The symptoms are about as humiliating as they come: crippling pain and diarrhoea full of blood…”

Photo of a woman

“I was too embarrassed to see my doctor…thoughts of an embarrassing procedure, having to do a stool test, all of that was dampening my desire to seek answers for my condition…”

Photo of a man

“I was depressed. I had to quit my job and for the first time since I’d been diagnosed, I started to seriously worry that my wife might leave me…”

Photo of a woman

“I am constantly fearful that I will have a flare-up, be hospitalised, or even worse, soil myself in public…”

Although the images above are fictional characters, the statements belong to real patients.

Time to look beyond the
symptoms of UC

Debilitating symptoms and the psychological stress associated with UC impede a patient’s normal life pursuits.1
Disease activity and psychological distress have been shown to significantly impair the QoL of individuals living with UC.1

The impact of UC on the personal lives of patients

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72%

have problems with sleep4,*,†
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43%

have depressive feelings4,*,†
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38%

have anxious feelings4,*,†
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29%

have problems participating in the community4,*
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25%

have problems with personal relationships4,*
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21%

have impairments in sexual function,5 with 31% of men and 80% of women with IBD reporting low or no interest in sex6
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29%

admit to self-medicating with oral steroids7

The impact of UC on the professional lives of patients

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Up to

98%

experience absenteeism (up to 60 days per patient year)8
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47%

report that UC influenced their career choice9,††
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50%

are unemployed5
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20%

have rejected a job9
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19%

are on disability pension5
* Data from 424 Dutch patients with UC who completed the IBD disability index (IBD-DI) after 2 years of follow-up. The IBD-DI has been reported to be reliable, reproducible, and sensitive for detecting disability.4
Percentage estimated from graphic data, ±1%.
†† Data from the UC-LIFE survey to assess patients’ perception of the impact of UC on their lives, conducted in 38 outpatient clinics in Spain. Survey response rate was 74.5% (436/585 UC patients).9

Patients report self-medication with steroids due to suspected clinical worsening
and fear of hospitalisation or need for sick leave.7

Both psychological interventions and effective medical therapy have demonstrated a positive impact on QoL.1

References:
  1. Jones JL, Nguyen GC, Benchimol EI, et al. J Can Assoc Gastroenterol. 2019;2(Suppl 1):S42-S48.
  2. Benchimol EI, Bernstein CN, Bitton A, et al. J Can Assoc Gastroenterol. 2019;2(Suppl 1):S1-S5.
  3. Bokemeyer B, Hardt J, Hüppe D, et al. J Crohns Colitis. 2013;7(5):355-368.
  4. van der Have M, Fidder HH, Leenders M, et al. Inflamm Bowel Dis. 2015;21(2):369-377.
  5. Danese S, Allez M, van Bodegraven AA, et al. Dig Dis. 2019;37(4):266‐283.
  6. Taft TH, Ballou S, Bedell A, Lincenberg D. Gastroenterol Clin North Am. 2017;46(4):847-858.
  7. Bernal I, Domènech E, Garcia-Planella E, et al. Dig Dis Sci. 2006;51(12):2165-2169.
  8. Constantin J, Atanasov P, Wirth D, Borsi A. BMC Gastroenterol. 2019;19(1):179.
  9. Calvet X, Argüelles-Arias F, López-Sanromán A, et al. Patient Prefer Adherence. 2018;12:1815-1823.
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